Riluzole Does Not Affect Hippocampal Synaptic Plasticity and Spatial Memory, Which Are Impaired by Diazepam in Rats

Riluzole Does Not Affect Hippocampal Synaptic Plasticity and Spatial Memory, Which Are Impaired by Diazepam in Rats

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We have previously demonstrated that riluzole here has anxiolytic-like effects in rats, without affecting spontaneous alternation performance in the Y-maze test.However, the effects of riluzole on hippocampal synaptic plasticity were still unclear.In this study, we showed that bath application of riluzole did not impair long-term potentiation and long-term depression, whereas a benzodiazepine anxiolytic, diazepam, significantly impaired them.Furthermore, the acquisition of spatial memory in the Morris water maze test was impaired in diazepam-treated but not riluzole-treated rats.

We thus provide further evidence for the potential usefulness of riluzole as an anxiolytic that does not cause amnesia.Keywords:: mood and anxiety apunisw2 disorder, amnesia, riluzole.